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The increased cost and additional injection requirement mean the combination approach represents a step up in commitment

However, low concentrations of doxorubicin do not induce apoptosis in cancer cells, but rather induce cellular senescence 25,26

In proteins, several electron-rich functional groups are susceptible to oxidation, such as sulfhy-dryl in cysteine, imidazole in histidine, thioether in methionine, phenol in tyrosine, and indole in tryptophan

The enzyme methionine synthase needs methylcobalamin as a cofactor